SMYD3 DRIVES CELL CYCLE AND EPITHELIAL-MESENCHYMAL TRANSITION PATHWAYS THROUGH DUAL GENE TRANSCRIPTIONAL REPRESSION AND ACTIVATION IN HPV-NEGATIVE HEAD AND NECK CANCER

Abstract Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type in the world and is associated with an overall poor prognosis.The protein methyltransferase SET and MYND domain-containing 3 (SMYD3), which trimethylates lovesense 3 H3K4, activates gene transcription and enhances several

Proterosuchidae represents the oldest substantial diversification of Archosauromorpha and plays a key role in understanding the biotic recovery after the end-Permian mass extinction.Proterosuchidae was long treated as a wastebasket taxon, but recent revisions have reduced its taxonomic content to five valid species from the latest Permian hbl5266ca